Sarcomatoid Mesothelioma: Complete Guide to Diagnosis, Treatment, and Prognosis

Sarcomatoid Mesothelioma


Sarcomatoid mesothelioma is a rare and aggressive form of cancer that primarily affects the mesothelial cells lining the lungs, heart, abdomen, or testicles. This subtype of mesothelioma is characterized by the presence of sarcomatoid cells, which are spindle-shaped and exhibit aggressive growth patterns. In this comprehensive guide, we will delve into the various aspects of sarcomatoid mesothelioma, including its diagnosis, treatment options, and prognosis.

Sarcomatoid Mesothelioma: Understanding the Disease

Mesothelioma is a type of cancer that develops in the thin layer of tissue, called the mesothelium, which covers the internal organs of the body. Sarcomatoid mesothelioma is one of the three main histological subtypes of mesothelioma, with the other two being epithelioid and biphasic. Sarcomatoid mesothelioma accounts for approximately 10-20% of all mesothelioma cases and is known for its aggressive nature and poor prognosis.

How does Sarcomatoid Mesothelioma Develop?

Sarcomatoid mesothelioma is primarily caused by prolonged exposure to asbestos, a naturally occurring mineral that was extensively used in various industries such as construction, shipbuilding, and manufacturing. Inhalation or ingestion of asbestos fibers can lead to their accumulation in the mesothelium, triggering cellular changes and the development of cancerous growths. However, it’s important to note that not all individuals exposed to asbestos develop mesothelioma, and there may be other factors involved in the development of the disease.

Symptoms and Early Detection

The symptoms of sarcomatoid mesothelioma are often nonspecific and can be mistaken for other respiratory or abdominal conditions. Some common symptoms include:

  • Persistent coughing
  • Shortness of breath
  • Chest pain
  • Unexplained weight loss
  • Fatigue
  • Abdominal swelling or pain

Early detection of sarcomatoid mesothelioma is challenging due to its aggressive nature and nonspecific symptoms. By the time the symptoms become apparent, the disease has usually reached an advanced stage. However, if you have a history of asbestos exposure or experience any of the aforementioned symptoms, it’s crucial to consult a healthcare professional for a thorough evaluation.

Diagnosing Sarcomatoid Mesothelioma

The diagnosis of sarcomatoid mesothelioma involves a series of tests and procedures to confirm the presence of the disease and determine its extent. These may include:

  1. Imaging tests: X-rays, CT scans, and MRI scans can help identify abnormalities and assess the extent of tumor growth.
  2. Biopsy: A biopsy is the definitive diagnostic procedure for mesothelioma. It involves the removal of a small tissue sample for laboratory analysis.
  3. Immunohistochemistry: This test uses specific antibodies to identify the presence of proteins associated with mesothelioma cells, aiding in the differentiation from other types of cancer.
  4. Genetic testing: Certain genetic mutations may be present in sarcomatoid mesothelioma, and genetic testing can help in targeted treatment options.

Sarcomatoid Mesothelioma

Treatment Options for Sarcomatoid Mesothelioma

The treatment approach for sarcomatoid mesothelioma depends on several factors, including the stage of the disease, overall health of the patient, and the extent of tumor spread. Treatment options may include a combination of surgery, chemotherapy, radiation therapy, and emerging therapies.


Surgical intervention aims to remove the tumor and surrounding affected tissue to the greatest extent possible. The surgical procedures commonly used for sarcomatoid mesothelioma include:

  • Extrapleural pneumonectomy (EPP): This extensive procedure involves removing the affected lung, the lining of the chest wall, the diaphragm, and nearby lymph nodes.
  • Pleurectomy/decortication (P/D): This surgery focuses on removing the tumor and the pleural lining of the affected lung, allowing the preservation of lung function.
  • Cytoreductive surgery: This procedure involves the removal of visible tumors in the abdominal cavity and may be combined with heated intraperitoneal chemotherapy (HIPEC).


Chemotherapy commonly used as an adjuvant therapy for sarcomatoid mesothelioma. It involves the administration of powerful drugs that target and kill cancer cells throughout the body. Some commonly used chemotherapy drugs for sarcomatoid cancer include pemetrexed and cisplatin.

Radiation Therapy

Radiation therapy uses high-energy beams to target and destroy cancer cells. It may be employed as a standalone treatment or in combination with surgery and chemotherapy to enhance treatment efficacy. External beam radiation therapy and brachytherapy are the two main types of radiation therapy used for sarcomatoid cancer.

Emerging Therapies

In recent years, advancements make in the field of mesothelioma research, leading to the development of novel treatment approaches. These include:

  • Immunotherapy: Immunotherapy drugs stimulate the body’s immune system to recognize and destroy cancer cells. Checkpoint inhibitors and immune checkpoint inhibitors can among the immunotherapies being investigate for sarcomatoid mesothelioma.
  • Targeted therapies: Targeted therapies involve drugs that specifically target certain genetic mutations or proteins associated with cancer cells. Clinical trials are ongoing to assess the effectiveness of targeted therapies for sarcomatoid mesothelioma.

Prognosis and Survival Rate

Sarcomatoid cancer has a generally poor prognosis compared to other subtypes of mesothelioma. The aggressive nature of the cancer and its resistance to traditional treatments contribute to the limited life expectancy associated with this disease. The overall survival rate for sarcomatoid mesothelioma is lower than 12 months on average, although individual cases may vary.

FAQs about Sarcomatoid Mesothelioma

Q: What is the difference between sarcomatoid mesothelioma and other types of mesothelioma?

Sarcomatoid is one of the three main histological subtypes of mesothelioma, along with epithelioid and biphasic. It characterized the presence of spindle-shaped sarcomatoid cells, which exhibit aggressive growth patterns. Epithelioid mesothelioma consists of cuboidal or columnar cells, while biphasic mesothelioma contains both epithelioid and cells.

Q: Can sarcomatoid cancer cure?

Curing sarcomatoid cancer is challenging due to its aggressive nature and resistance to treatment. However, advancements in research and emerging therapies offer hope for improved outcomes and increased survival rates.

Q: Are there any clinical trials available for sarcomatoid cancer?

Yes, there are several ongoing clinical trials exploring new treatment approaches and therapies specifically targeting sarcomatoid . Participation in clinical trials can provide access to innovative treatments and contribute to the advancement of medical knowledge.

Q: Can sarcomatoid cancer prevented?

The primary cause of sarcomatoid cancer is asbestos exposure. Preventing exposure to asbestos is the most effective way to reduce the risk of developing this type of cancer. Strict regulations and safety measures in industries that handle asbestos are crucial for preventing occupational exposure.

Q: What should I do if I have diagnosed with sarcomatoid?

If you have diagnosed with sarcomatoid cancer, it is essential to seek treatment from a specialized mesothelioma medical team. They can provide you with the most up-to-date treatment options, support, and guidance throughout your journey.

Q: How can I support a loved one diagnosed with mesothelioma?

Supporting a loved one with mesothelioma involves being there for them emotionally, offering practical assistance, and educating yourself about the disease. Joining support groups and seeking guidance from healthcare professionals can also be beneficial for both the patient and their loved ones.


Sarcomatoid cancer is a rare and aggressive form of cancer that poses significant challenges to diagnosis, treatment, and prognosis. Understanding the disease, its symptoms, and available treatment options is crucial for patients, their families, and healthcare providers. Ongoing research and advancements in treatment approaches offer hope for improved outcomes and increased survival rates. If you or someone you know can affect sarcomatoid cancer. It is essential to consult with medical professionals specializing in mesothelioma for personalized care and support.

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